SHERIFF: Can I help you boys?
DEAN: No sir, we were just leaving. Agent Mulder, Agent Scully.
1×04 PHANTOM TRAVELER
DEAN: All right, this is gonna sound nuts, but we just don’t have time for the whole “The truth is out there” speech right now.
2×05 SIMON SAID
SAM: Dean! Andy’s got the Impala!
DEAN: I know! He just sorta asked me for it and I, I let him take it.
SAM: You what?
DEAN: He full-on Obi-Wanned me. It’s mind control, man!
1×17 HELL HOUSE
DEAN: Who ya gonna call?
[Ed Zeddmore and Harry Spengler surnames refere to the characters from Ghostbusters: Winston Zeddmore and Egon Spengler.]
2×06 NO EXIT
SAM: What’s that?
SAM: Holy crap.
DEAN: That’s ectoplasm. Well, Sam, I think I know what we’re dealing with here. It’s the Stay-Puff Marshmallow Man.
2×18 HOLLYWOOD BABYLON
The Winchesters are on a tour of Hollywood. The tour guide says that they are passing the place where Gilmore Girls (2000) is filmed, and if they’re lucky they might get to see one of the stars. Jared Padalecki, who plays Sam Winchester, had a starring role on Gilmore Girls (2000), playing a character named Dean Forester. At this point, Sam Winchester looks uncomfortable and quickly leaves the tour bus.